Propionic Acid → HCID 178460234, 화합물

반응식

Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)[CH:5]=[CH:4]1.[C:27](O)(=[O:30])[CH2:28][CH3:29]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:27](=[O:30])[CH2:28][CH3:29])[CH2:24][CH2:25]2)[CH:5]=[CH:4]1

참가 물질

반응물 2

HCID 1032Propionic Acid

HCID 178478712HCID 178478712, 화합물2회

생성물 1

HCID 178460234HCID 178460234, 화합물

실험 절차

The title compound, off-white solid (84 mg, 76%), MS (ISP) m/z=383.4 [(M+H)+], mp 170° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl-amine dihydrochloride (intermediate A) (115 mg, 0.29 mmol) and propionic acid.

출처 및 근거

ORD 기록: ord-c9ed8dad34824dcab9de58c00b48c0b2
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08877778B2

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