4-Quinolinecarboxylic acid → HCID 178523602, 화합물

반응식

Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[N:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:30]([C:37](O)=[O:38])=[CH:29][CH:28]=1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:37]([C:30]5[C:31]6[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=6)[N:27]=[CH:28][CH:29]=5)=[O:38])[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

참가 물질

반응물 2

HCID 102434-Quinolinecarboxylic acid

HCID 178478710HCID 178478710, 화합물2회

생성물 1

HCID 178523602HCID 178523602, 화합물

실험 절차

The title compound, light brown solid (98 mg, 82%), MS (ISP) m/z=484.5 [(M+H)+], mp 211° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and quinoline-4-carboxylic acid.

출처 및 근거

ORD 기록: ord-cc4c537e424a4cee8635d011b9bf8f0a
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08877778B2

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