3-Hydroxyisovaleric acid → HCID 178459206, 화합물

HRID 331472

반응식

HRID 331472 반응식
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[OH:27][C:28]([CH3:34])([CH3:33])[CH2:29][C:30](O)=[O:31]>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:30](=[O:31])[CH2:29][C:28]([OH:27])([CH3:34])[CH3:33])[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

참가 물질

3

반응물 2

HCID 693623-Hydroxyisovaleric acidHCID 178478710HCID 178478710, 화합물2회

생성물 1

HCID 178459206HCID 178459206, 화합물

실험 절차

The title compound, white solid (65 mg, 61%), MS (ISP) m/z=429.4 [(M+H)+], mp 168° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 3-hydroxy-3-methyl-butyric acid.

출처 및 근거

ORD 기록
ord-f5461a7af34f45029e56e041fc9dff8b
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877778B2

연결된 노트

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