Methyl 3,3-dimethoxypropionate → HCID 178495574, 화합물

HRID 331482

반응식

HRID 331482 반응식
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[CH3:27][O:28][CH:29]([O:35][CH3:36])[CH2:30][C:31](OC)=[O:32]>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:31](=[O:32])[CH2:30][CH:29]([O:35][CH3:36])[O:28][CH3:27])[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

참가 물질

3

반응물 2

HCID 81924Methyl 3,3-dimethoxypropionateHCID 178478710HCID 178478710, 화합물2회

생성물 1

HCID 178495574HCID 178495574, 화합물

실험 절차

The title compound, white solid (85 mg, 77%), MS (ISP) m/z=445.3 [(M+H)+], mp 240° C., was prepared in accordance with the general method of example 81 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and methyl 3,3-dimethoxy-propanoate.

출처 및 근거

ORD 기록
ord-160904b9a80e427d9bee50900578f55f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877778B2

연결된 노트

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