4-(1H-Pyrrol-1-yl)benzoic acid → HCID 178523594, 화합물

HRID 331490

반응식

HRID 331490 반응식
Cl.Cl.[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1.[N:27]1([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH:31]=[CH:30][CH:29]=[CH:28]1>>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C@H:20]4[CH2:21][CH2:22][C@H:23]([NH:26][C:36](=[O:37])[C:35]5[CH:39]=[CH:40][C:32]([N:27]6[CH:31]=[CH:30][CH:29]=[CH:28]6)=[CH:33][CH:34]=5)[CH2:24][CH2:25]4)[CH2:14][CH2:13]3)[C:6]=2[CH2:5][CH2:4]1

참가 물질

3

반응물 2

HCID 27372564-(1H-Pyrrol-1-yl)benzoic acidHCID 178478710HCID 178478710, 화합물2회

생성물 1

HCID 178523594HCID 178523594, 화합물

실험 절차

The title compound, light brown solid (90 mg, 73%), MS (ISP) m/z=498.4 [(M+H)+], mp 228° C., was prepared in accordance with the general method of example 1 from trans-4-{2-[4-(2,3-dihydro-benzofuran-4-yl)-piperidin-1-yl]-ethyl}-cyclohexylamine dihydrochloride (intermediate B) (100 mg, 0.25 mmol) and 4-pyrrol-1-yl-benzoic acid.

출처 및 근거

ORD 기록
ord-584848a685a043db87948f6134b178aa
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877778B2

연결된 노트

불러오는 중…