Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloroquinoline | HCID 11928 | — |
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate | HCID 16117834 | — |
반응 단계
A mixture of 6.1 mmol 2-chloroquinoline, 6.7 mmol piperazine-1-carboxylic acid tert-butyl ester and 12.2 mmol potassium carbonate in 15 ml acetonitrile was refluxed overnight. The reaction mixture is concentrated, water is added and the compound extracted with ethyl acetate. Chromatography (SiO2; cyclohexane/ethyl acetate 9/1) gave the title compound as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429585B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a686448e25f6428e9d95799ac3023fb6 |
| 출처 메모 | uspto-grants-2008_09 |