tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

HRID 33169

반응식

HRID 33169 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=2)[N:3]=1.[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=3)[N:3]=2)[CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:14])[CH3:15]

참가 물질

3

반응물 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 6075022,6-Dichloroquinoline

생성물 1

HCID 58906309Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

실험 절차

Prepared in analogy to example 1.18(a) from 2,6-dichloroquinoline and piperazine-1-carboxylic acid tert-butyl ester. Crystallisation from methanol yields the title compound as a colorless solid.

후처리

  1. customCrystallisation from methanol

출처 및 근거

ORD 기록
ord-e0438a7b174843c8a39e6fdf9ab17a95
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429585B2

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