참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Iodobenzonitrile | HCID 144341 | — |
| 반응물 | 1-Chloro-4-{1-[(E)-2-nitroethenyl]cyclobutyl}benzene | HCID 66746852 | — |
| 반응물 | HCID 178418918 | HCID 178418918 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 66747575 | HCID 66747575 | — |
반응 단계
3-Iodobenzonitrile (3.76 g, 16.41 mmol) dissolved in tetrahydrofuran (1.5 ml) was cooled to −30° C. A solution of isopropylmagnesium chloride in tetrahydrofuran (2 M, 8.84 ml, 17.67 mmol) was added dropwise at −30° C. over 25 min. The reaction mixture was cooled to −78° C. A solution of (E)-1-chloro-4(1-(2-nitrovinyl)cyclobutyl)benzene (3.0 g, 12.62 mmol) in tetrahydrofuran (0.5 ml) was added dropwise. Aqueous work-up yielded the desired product which was used without further purification for the next step. Yield: 3.3 g (8.71 mmol, 69%, purity: 90% by HPLC)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08877794B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
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| ORD ID | ord-6f6116da9c62469bae9305d10c9e8dcb |
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| 출처 메모 | uspto-grants-2014_11 |
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