반응식
C(OC([N:6]1[CH2:9][C:8]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][CH2:18][NH:19][S:20]([CH2:23][CH:24]3[CH2:26][CH2:25]3)(=[O:22])=[O:21])[CH:11]=2)[CH2:7]1)=O)C.[OH-].[Na+].CCO>[Cl-].[Na+].O>[CH2:27]([C:8]1([C:10]2[CH:11]=[C:12]([CH:13]=[CH:14][CH:15]=2)[O:16][CH2:17][CH2:18][NH:19][S:20]([CH2:23][CH:24]2[CH2:25][CH2:26]2)(=[O:22])=[O:21])[CH2:7][NH:6][CH2:9]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
To 3-benzyl-3-[3-(2-cyclopropylmethanesulfonylamino-ethoxy)-phenyl]-azetidine-1-carboxylic acid ethyl ester (50 mg, 0.11 mmol) was added 4 ml 2N NaOH/EtOH. The mixture was heated for 1 hour in a microwave. After cooling to room temperature 50% brine was added and the mixture extracted with dichloromethane. The combined organic layers were washed with brine, dried over sodium bicarbonate, filtered and the solvent evaporated. The residue was purified on 4 g SiO2 using 10% methanol in dichloromethane affording the desired product as a clear oil. m=15.5 mg
후처리
- temperatureThe mixture was heated for 1 hour in a microwave
- additionwas added
- extractionthe mixture extracted with dichloromethane
- washThe combined organic layers were washed with brine
- dry with materialdried over sodium bicarbonate
- filtrationfiltered
- customthe solvent evaporated
- customThe residue was purified on 4 g SiO2 using 10% methanol in dichloromethane affording the desired product as a clear oil
출처 및 근거
- ORD 기록
- ord-b45ddf19bd5e48ad84259f297dd38baa
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877794B2
연결된 노트
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