Potassium Iodide → tert-Butyl 4-(quinoxalin-2-yl)piperazine-1-carboxylate

HRID 33174

반응식

HRID 33174 반응식
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C1(C)C=CC=CC=1.O>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:11]=[N:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2389382-Chloroquinoxaline

생성물 1

HCID 25070624tert-Butyl 4-(quinoxalin-2-yl)piperazine-1-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

A mixture of 9.1 mmol 2-chloroquinoxaline, 10.0 mmol piperazine-1-carboxylic acid tert-butyl ester, 22.8 mmol potassium carbonate and 2.1 mmol potassium iodide in 20 ml of toluene was refluxed overnight. The reaction mixture was cooled, poured into water and extracted 3 times with ethyl acetate. The organic phase was dried, evaporated and the title compound was crystallised from methanol. Yellowish solid.

후처리

  1. temperaturewas refluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted 3 times with ethyl acetate
  4. customThe organic phase was dried
  5. customevaporated
  6. customthe title compound was crystallised from methanol

출처 및 근거

ORD 기록
ord-733e9c2c38b94ae1a26504d1d171a4d4
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429585B2

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