HCID 42628942, 화합물 → HCID 68445203, 화합물

HRID 331776노트

반응식

HRID 331776 반응식
[CH:1]([NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2].[CH3:27]C1ON=C(C2C=CC=CC=2)C=1COC1C=CC(C(NC2CCOCC2)=O)=CN=1>>[CH:1]([N:4]([CH3:27])[C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 42628942HCID 42628942, 화합물HCID 575200146-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

생성물 1

HCID 68445203HCID 68445203, 화합물수율 33%

실험 절차

As described for example 50, N-isopropyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide (200 mg, 0.6 mmol), instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide, was converted to the title compound (69 mg, 33%) which was obtained as a colourless gum. MS: m/e=366.3 [M+H]+.

출처 및 근거

ORD 기록
ord-ab0abae683e14121ba056128912081c5
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877782B2

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