3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester → [3-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol

HRID 332001노트

반응식

HRID 332001 반응식
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][N:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=O)C.C(OC(C1C(C2C=CC(F)=CN=2)=NOC=1C)=O)C>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:7]2[C:6]([CH2:4][OH:3])=[C:10]([CH3:11])[O:9][N:8]=2)=[N:13][CH:14]=1

참가 물질

3

반응물 2

HCID 665990603-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl esterHCID 671575733-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester

생성물 1

HCID 67157504[3-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol수율 73.2%

실험 절차

As described for example 286c, 3-(5-chloro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (1.26 g, 4.7 mmol) was converted, instead of 3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (773 mg, 73%) which was obtained as an off white solid. MS: m/e=224.9 [M+H]+.

출처 및 근거

ORD 기록
ord-d8be5d61d2aa4f5993ac781958b04ea4
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877782B2

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