Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Propanol, 3-amino-2,2-dimethyl- → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-2,2-dimethyl-propyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Propanol, 3-amino-2,2-dimethyl- | HCID 117326 | — |
| 반응물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| 생성물 | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-2,2-dimethyl-propyl)-nicotinamide | HCID 68444175 | 60% |
반응 단계
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using 3-amino-2,2-dimethyl-1-propanol instead of ethanolamine, to the title compound (150 mg, 60%) which was obtained as a white solid. MS: m/e=414.1 [M−H]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877782B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-a8d9303a59d24265bec1c00b4ad126b2 |
| 출처 메모 | uspto-grants-2014_11 |