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C([O:3][C:4]([C:6]1[C:7]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][N:12]=2)=[N:8][O:9][CH:10]=1)=[O:5])C.C(OC(C1C(C2C=CC=CN=2)=NOC=1)=O)C>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][O:9][N:8]=2)=[N:12][CH:13]=1참가 물질
3
실험 절차
As described for example 358b, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.
출처 및 근거
- ORD 기록
- ord-1db2ec08134d43b9b044ddfc53b3b42f
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877782B2
연결된 노트
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