Potassium Carbonate → 5-chloro-2-(((1-propyl-1H-imidazol-4-yl)methyl)thio)aniline

HRID 332151

반응식

HRID 332151 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[SH:9].Cl[CH2:11][C:12]1[N:13]=[CH:14][N:15]([CH2:17][CH2:18][CH3:19])[CH:16]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:11][C:12]2[N:13]=[CH:14][N:15]([CH2:17][CH2:18][CH3:19])[CH:16]=2)=[C:2]([CH:7]=1)[NH2:1]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 120002-Amino-4-chlorobenzenethiolHCID 229385374-(chloromethyl)-1-propyl-1H-imidazole

생성물 1

HCID 679722445-chloro-2-(((1-propyl-1H-imidazol-4-yl)methyl)thio)aniline수율 67%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(1-propyl-1H-imidazol-4-yl)methanol (535 mg, 3.11 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at 35° C. for 2 hrs. The solvent was removed to get a crude 4-(chloromethyl)-1-propyl-1H-imidazole. Then following General Procedure A, the title compound (587 mg, 67%) was prepared from 2-amino-4-chlorobenzenethiol (744 mg, 4.66 mmol), 4-(chloromethyl)-1-propyl-1H-imidazole, K2CO3 (2.1 g, 15.54 mmol) in DMF (10 ml).

출처 및 근거

ORD 기록
ord-185fac4488aa4c26a7068f3febcdb4d2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877804B2

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