Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloropyridine → tert-Butyl [1-(pyridin-4-yl)piperidin-4-yl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloropyridine | HCID 12288 | — |
| 반응물 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | n-butanol water NEt3 | HCID 86625244 | — |
| 생성물 | tert-Butyl [1-(pyridin-4-yl)piperidin-4-yl]carbamate | HCID 18008972 | — |
반응 단계
A solution of 3 g Piperidin-4-yl-carbamic acid tert-butyl ester and 2.5 g 4-Chloropyridine in 9 ml n-butanol/water/NEt3 1:1:1 was heated at 100° C. for 48 h. Then the solution was cooled to RT diluted with DCM and washed with NaHCO3 solution and water. The organic layer was dried over Na2SO4, filtered, and the solvent was removed under reduced pressure. Chromatographic purification of the residue on silica with DCM as eluent gave after evaporation of the fractions containing the product a white foam. Yield 1.7 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429581B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-67cb0225ae7f4dc89bfb109598d6f565 |
| 출처 메모 | uspto-grants-2008_09 |