Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Propan-2-yloxy)ethan-1-amine → N-(2-Isopropoxy-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Propan-2-yloxy)ethan-1-amine | HCID 533866 | — |
| 반응물 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 66599213 | — |
| 생성물 | N-(2-Isopropoxy-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68444367 | 74% |
반응 단계
As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.65 mmol) was converted, using 2-aminoethyl isopropylether instead of methylamine, to the title compound (190 mg, 74%) which was obtained as a white solid. MS: m/e=454.1 [M+OAc]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877783B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-6469f36da6404856a96e84933ab91e5a |
| 출처 메모 | uspto-grants-2014_11 |