Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Prolinol, (R)- → ((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Prolinol, (R)- | HCID 2724541 | — |
| 반응물 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 66599292 | — |
| 생성물 | ((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone | HCID 42629928 | 96% |
반응 단계
As described for example 223, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (120 mg, 0.37 mmol) was converted, using D-prolinol instead of L-prolinol, to the title compound (139 mg, 96%) which was obtained as a colourless oil. MS: m/e=394.1 [M+H]′.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877783B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-ab6690038b6a46bbbd5430d224327921 |
| 출처 메모 | uspto-grants-2014_11 |