Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetaldehyde ammonia → (2-Hydroxy-ethyl)-6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetaldehyde ammonia | HCID 522583 | — |
| 반응물 | 6-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 42630170 | — |
| 반응물 | 6-[3-(3-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68444859 | — |
| 생성물 | (2-Hydroxy-ethyl)-6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68442696 | 24% |
반응 단계
As described for example 98b, 6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (77.8 mg, 0.25 mmol) was converted, instead of 6-[3-(3-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid, using aminoethanol instead of 2,2,2-trifluoroethylamine, to the title compound (21 mg, 24%) which was obtained as a white solid. MS: m/e=355.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877783B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-1d7c9208c5e9462392faa1aa8f330471 |
| 출처 메모 | uspto-grants-2014_11 |