Trifluoroacetic acid → (2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

HRID 332605노트

반응식

HRID 332605 반응식
[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13]([CH:16]=[CH:17][C:18]([O:20]C(C)(C)C)=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 779345505-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester

생성물 1

HCID 70869499(2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

실험 절차

To 5-(2-tert-butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester (0.15 g, 0.46 mmol) obtained in Example 41, step 2 was added trifluoroacetic acid (3 ml), and the mixture was stirred for 30 minutes. The solvent was evaporated under reduced pressure to give the title compound.

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-19c8c9a010e74a4eaa4ffeb253461364
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877805B2

반응 노트

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