Methanol → L-cysteic acid methyl ester hydrochloride

HRID 332609

반응식

HRID 332609 반응식
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

생성물 1

HCID 86673321L-cysteic acid methyl ester hydrochloride수율 75%

실험 절차

L-cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

출처 및 근거

ORD 기록
ord-2050740cabfa4238933a646dca392ceb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877805B2

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