p-Toluenesulfonic acid → Methyl 3-benzoylbenzoate

HRID 332688

반응식

HRID 332688 반응식
[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18]C1C=CC(S(O)(=O)=O)=CC=1>CO>[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([O:14][CH3:18])=[O:13])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 1013863-Benzoylbenzoic acid

생성물 1

HCID 349621Methyl 3-benzoylbenzoate수율 905.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A stirred solution of 3-benzoylbenzoic acid (10.0 g, 44.4 mmol) and p-TSA (0.85 g, 4.39 mmol) in methanol (200 mL) was heated at 75° C. for 18 hours. The reaction mixture was allowed to cool, and the solvent evaporated at reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The organic phase was dried with anhydrous sodium sulfate, filtered, and the filtrate was evaporated at reduced pressure to afford the title compound (9.55 g, 90%).

후처리

  1. temperatureto cool
  2. customthe solvent evaporated at reduced pressure
  3. customThe residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic phase was dried with anhydrous sodium sulfate
  5. filtrationfiltered
  6. customthe filtrate was evaporated at reduced pressure

출처 및 근거

ORD 기록
ord-d39238a40f694b9b81a0d9f53718ff8e
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877774B2

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