Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3,5-Dichloropyrazine-2-carbonitrile | HCID 52987744 | — |
| 반응물 | (R)-2-Amino-4-methylpentanamide hydrochloride | HCID 56776963 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide | HCID 86685528 | 99.9% |
반응 단계
A solution of 3,5-dichloropyrazine-2-carbonitrile (348 mg, 2.00 mmol), D-leucinamide hydrochloride (333 mg, 2.00 mmol) and DIEA (1.00 mL, 5.75 mmol) in NMP (8 mL) was stirred at room temperature for 20 h. Water and EtOAc were added. Organic phase was separated, dried over Na2SO4, concentrated in vacuo to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide as an oil (535 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877760B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-0385adcc6f644b019f4da24fcf50a9c5 |
| 출처 메모 | uspto-grants-2014_11 |