Potassium Carbonate → HCID 86685577, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Binap, (A+-)-	HCID 634876	—
반응물	6-amino-3,4-dihydroquinolin-2(1H)-one	HCID 4912759	—
반응물	5-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-3-chloropyrazine-2-carbonitrile	HCID 86685556	—
촉매	palladium(II) acetate	HCID 167845	—
용매	1,4-Dioxane	HCID 31275	—
생성물	HCID 86685577	HCID 86685577	42.4%

반응 단계

A mixture of 5-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-3-chloropyrazine-2-carbonitrile (74 mg, 0.257 mmol), 6-amino-3,4-dihydroquinolin-2(1H)-one (50 mg, 0.308 mmol), K2CO3 (80 mg, 0.579 mmol), BINAP (25 mg, 0.040 mmol) and Pd(OAc)2 (15 mg, 0.066 mmol) in dioxane (2 mL) was degassed with Ar, then was stirred at 110 C for 4 h. The mixture was concentrated in vacuo. The residue was purified by HPLC to give 5-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-3-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)pyrazine-2-carbonitrile (45 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08877760B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-414e3c79207449d89cd32f06160f21a9
출처 메모	uspto-grants-2014_11