Potassium Carbonate → (R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(Pyridin-3-yl)aniline	HCID 459522	—
반응물	Binap, (A+-)-	HCID 634876	—
반응물	(R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)butanamide	HCID 86685581	—
촉매	palladium(II) acetate	HCID 167845	—
용매	1,4-Dioxane	HCID 31275	—
생성물	(R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide	HCID 86685585	57.8%

반응 단계

A mixture of (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)butanamide (100 mg, 0.417 mmol), 4-(pyridin-3-yl)aniline (77 mg, 0.452 mmol), K2CO3 (100 mg, 0.724 mmol), BINAP (30 mg, 0.048 mmol) and Pd(OAc)2 (15 mg, 0.066 mmol) in dioxane (3 mL) was degassed with Ar, then was stirred at 110 C for 20 h. The mixture was concentrated in vacuo. The residue was purified by HPLC to give (R)-2-(5-cyano-6-(4-(pyridin-3-yl)phenylamino)pyrazin-2-ylamino)butanamide (90 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08877760B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-7f8633bf2a204d9abc95189d4f933d76
출처 메모	uspto-grants-2014_11