Potassium Carbonate → HCID 86685586, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Binap, (A+-)-	HCID 634876	—
반응물	6-amino-3,4-dihydroquinolin-2(1H)-one	HCID 4912759	—
반응물	(R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)butanamide	HCID 86685581	—
촉매	palladium(II) acetate	HCID 167845	—
용매	1,4-Dioxane	HCID 31275	—
생성물	HCID 86685586	HCID 86685586	59%

반응 단계

A mixture of (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)butanamide (80 mg, 0.334 mmol), 6-amino-3,4-dihydroquinolin-2(1H)-one (60 mg, 0.370 mmol), K2CO3 (100 mg, 0.724 mmol), BINAP (25 mg, 0.040 mmol) and Pd(OAc)2 (10 mg, 0.044 mmol) in dioxane (2 mL) was degassed with Ar, then was stirred at 110 C for 4 h. The mixture was concentrated in vacuo. The residue was purified by HPLC to give (R)-2-(5-cyano-6-(2-oxo-1,2,3,4-tetrahydroquinolin-6-ylamino)pyrazin-2-ylamino)butanamide (72 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08877760B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-77271ab94614443fb5becbfe526e2306
출처 메모	uspto-grants-2014_11