Hydrogen Peroxide → Thieno[3,2-c]isothiazol-3-amine

HRID 332824노트

반응식

HRID 332824 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[S:9])[NH2:8].OO>CO>[N:1]1[S:9][C:7]([NH2:8])=[C:3]2[S:4][CH:5]=[CH:6][C:2]=12

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 143211023-Amino-2-thiophenecarbothioamide

생성물 1

HCID 818861Thieno[3,2-c]isothiazol-3-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of crude 3-aminothiophene-2-carbothioamide in MeOH (5 mL) was added H2O2 (30%, 0.6 mL), after stirring at room temperature for 15 min, it was concentrated to remove most of MeOH, and then diluted with EtOAC, organic layer was washed with brine, concentrated to give crude pdt, purification by column chromatography (DCM/EtOAC=3:1) gave thieno[3,2-c]isothiazol-3-amine (334 mg).

후처리

  1. concentrationit was concentrated
  2. customto remove most of MeOH
  3. additiondiluted with EtOAC, organic layer
  4. washwas washed with brine
  5. concentrationconcentrated
  6. customto give crude
  7. custompdt, purification by column chromatography (DCM/EtOAC=3:1)

출처 및 근거

ORD 기록
ord-a1f972cb6cc74047a95768c34fd755ab
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877760B2

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