p-Toluenesulfonate → Sorafenib Tosylate

HRID 332936

반응식

HRID 332936 반응식
[S:1]([C:5]1[CH:11]=[CH:10][C:8]([CH3:9])=[CH:7][CH:6]=1)([O-:4])(=[O:3])=[O:2].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:22][C:23]2[CH:39]=[CH:38][C:26]([O:27][C:28]3[CH:33]=[CH:32][N:31]=[C:30]([C:34]([NH:36][CH3:37])=[O:35])[CH:29]=3)=[CH:25][CH:24]=2)=[O:21])=[CH:15][C:14]=1[C:40]([F:43])([F:42])[F:41]>CO>[S:1]([C:5]1[CH:11]=[CH:10][C:8]([CH3:9])=[CH:7][CH:6]=1)([OH:4])(=[O:3])=[O:2].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:22][C:23]2[CH:39]=[CH:38][C:26]([O:27][C:28]3[CH:33]=[CH:32][N:31]=[C:30]([C:34]([NH:36][CH3:37])=[O:35])[CH:29]=3)=[CH:25][CH:24]=2)=[O:21])=[CH:15][C:14]=1[C:40]([F:43])([F:41])[F:42]

참가 물질

4

반응물 2

HCID 85570p-ToluenesulfonateHCID 216239Sorafenib

생성물 1

HCID 406563Sorafenib Tosylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3.5 g of the tosylate salt of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)-amino]phenoxy}-N-methylpyridine-2-carboxamide in the polymorph II are suspended in 15 ml of methanol and stirred at room temperature. After one week, the suspension is filtered and the residue dried at room temperature. Subsequently, the product is heat-treated at 150° C. for 30 min. The residue is analyzed by X-ray diffractometry and corresponds to the title compound in the polymorph III.

후처리

  1. waitAfter one week
  2. filtrationthe suspension is filtered
  3. customthe residue dried at room temperature
  4. additionSubsequently, the product is heat-treated at 150° C. for 30 min

출처 및 근거

ORD 기록
ord-21e034fe98d94e6bb1f2b10d3807ccd0
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877933B2

연결된 노트

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