(R)-1-(3-methylbutanoyl)piperidine-3-carboxylic acid → (R)-1-(3-(hydroxymethyl)piperidin-1-yl)-3-methylbutan-1-one

HRID 332994노트

반응식

HRID 332994 반응식
[CH3:1][CH:2]([CH3:15])[CH2:3][C:4]([N:6]1[CH2:11][CH2:10][CH2:9][C@@H:8]([C:12](O)=[O:13])[CH2:7]1)=[O:5]>C1COCC1>[OH:13][CH2:12][C@@H:8]1[CH2:9][CH2:10][CH2:11][N:6]([C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[CH3:15])[CH2:7]1

참가 물질

3

반응물 1

HCID 42257258(R)-1-(3-methylbutanoyl)piperidine-3-carboxylic acid

생성물 1

HCID 28345459(R)-1-(3-(hydroxymethyl)piperidin-1-yl)-3-methylbutan-1-one수율 7.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (R)-1-(3-methylbutanoyl)piperidine-3-carboxylic acid (Example 34d) (2.52 g, 11.84 mmol) in THF (20 mL) at 0° C., was added BH3Me2S (1.2 mL, 13.0 mmol) dropwise over 15 minutes. The reaction was warmed to room temperature and stirred overnight, cooled to 0° C., quenched with water, concentrated under reduced pressure to remove THF and extracted with EtOAc. The combined extracts were washed with saturated aqueous NaHCO3, dried over Na2SO4, filtered, concentrated under reduced pressure and purified by flash chromatography on silica gel (EtOAc/hexanes) to give the title compound (184 mg, 6%). MS 200 (MH+).

후처리

  1. temperaturecooled to 0° C.
  2. customquenched with water
  3. concentrationconcentrated under reduced pressure
  4. customto remove THF
  5. extractionextracted with EtOAc
  6. washThe combined extracts were washed with saturated aqueous NaHCO3
  7. dry with materialdried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated under reduced pressure
  10. custompurified by flash chromatography on silica gel (EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-19be4ec9642447e781abc30f743457c0
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877922B2

반응 노트

불러오는 중…