2,4-Dichloroquinoline → 4-Chloro-2-methoxyquinoline

HRID 333054

반응식

HRID 333054 반응식
Cl[C:2]1[CH:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([O:14][CH3:13])[CH:11]=1

참가 물질

4

반응물 2

HCID 6075032,4-DichloroquinolineHCID 10942334Sodium Methoxide

생성물 1

HCID 109653774-Chloro-2-methoxyquinoline수율 86%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a solution of (2.5 g, 12.6 mmol) 2,4-dichloro-quinoline in anhydrous toluene (20 ml) was added a suspension of solid sodium methoxide (2.5 g, 46.3 mmol) in anhydrous toluene (20 ml). The mixture was stirred under reflux for 16 hours and then allowed to cool to room temperature. The solid that had formed was filtered off and washed with 50 ml toluene. The filtrate was evaporated to dryness under reduced pressure to yield a red solid (2.1 g, 10.8 mmol, 86%). MS (ES) m/z=193.1 [M+H]+.

후처리

  1. temperatureunder reflux for 16 hours
  2. customThe solid that had formed
  3. filtrationwas filtered off
  4. washwashed with 50 ml toluene
  5. customThe filtrate was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-48e1dd726a364dd0af1d0b5699513a2f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877934B2

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