4-Iodobenzoyl chloride → HCID 68861098, 화합물

HRID 333124

반응식

HRID 333124 반응식
[NH2:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[N:4][N:3]=1.[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>N1C=CC=CC=1>[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:1][C:2]2[S:6][C:5]([S:7](=[O:9])(=[O:8])[NH2:10])=[N:4][N:3]=2)=[O:17])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 743734-Iodobenzoyl chlorideHCID 847245-Amino-1,3,4-thiadiazole-2-sulfonamide

생성물 1

HCID 68861098HCID 68861098, 화합물수율 13.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 5-amino-1,3,4-thiadiazole-2-sulfonamide (0.133 g, 0.50 mmol) in pyridine (5.0 mL) was added 4-iodobenzoyl chloride (0.162 g, 0.75 mmol). The reaction mixture was stirred at room temperature for overnight under nitrogen. Solvent was concentrated and water (60 mL) was added the mixture. The precipitated sulfonamide was filtered and dried over vacuum to give desired compound (27.3 mg, 13%) as a white solid.

후처리

  1. concentrationSolvent was concentrated
  2. additionwater (60 mL) was added the mixture
  3. filtrationThe precipitated sulfonamide was filtered
  4. customdried over vacuum

출처 및 근거

ORD 기록
ord-250ae31a92204fd3b323f242a4f44623
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877970B2

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