Potassium Cyanide → 2-(6-Fluoronaphthalen-2-yl)acetonitrile
반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([F:13])[CH:9]=2)[CH:4]=1.[C-:14]#[N:15].[K+]>CC#N>[F:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([CH2:2][C:14]#[N:15])[CH:12]=[CH:11]2참가 물질
4
실험 절차
To a mixture of 2-bromomethyl-6-fluoro-naphthalene (1.5 g, 5.9 mmoL) in CH3CN (30 mL) was added KCN (1.16 g, 17.8 mmoL). The reaction mixture was heated at reflux for 6 h before being concentrated. To the residue was added diethyl ether (100 mL) and H2O (15 mL). The organic layer was separated, dried and concentrated. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10) to afford the (6-fluoro-naphthalen-2-yl)-acetonitrile (0.88 g, 70%).
후처리
- temperatureThe reaction mixture was heated
- temperatureat reflux for 6 h
- concentrationbefore being concentrated
- additionTo the residue was added diethyl ether (100 mL) and H2O (15 mL)
- customThe organic layer was separated
- customdried
- concentrationconcentrated
- customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10)
출처 및 근거
- ORD 기록
- ord-c8ed129c803a4f8e812b07320838c9a0
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877975B2
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