Trifluoroacetic acid → HCID 178511761, 화합물

HRID 333338노트

반응식

HRID 333338 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C@H:15]([NH:21]C(=O)OC(C)(C)C)[C:16]3[NH:20][N:19]=[N:18][N:17]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][C@@H:15]([C:16]3[NH:20][N:19]=[N:18][N:17]=3)[NH2:21])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178454141(S)-Tert-butyl 2-(3'-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamate

생성물 1

HCID 178511761HCID 178511761, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (S)-tert-butyl 2-(3′-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamate (250 mg, 0.625 mmol) in DCM (5 ml) at room temperature was added TFA (2 ml, 26.0 mmol), and the mixture was stirred at room temperature for 0.5 hour. The mixture was concentrated under reduced pressure and obtained the title compound. LCMS (condition A): 300.1 (M+1); retention time=1.20 min.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6dfb14583bc747ca8fac8a37b3df17bb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877815B2

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