Dichloromethane → N-(6-Cyanohexanoyl)glycine, ethyl ester

HRID 3335

반응식

HRID 3335 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8].[C-:16]#[N:17].[K+].ClCCl>C(O)C>[C:16]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8])#[N:17]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 9032Potassium CyanideHCID 86154941N-(6-bromohexanoyl)-glycine, ethyl ester

생성물 1

HCID 85707690N-(6-Cyanohexanoyl)glycine, ethyl ester수율 99%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

23.73 g (84.7·10-3 mol) of N-(6-bromohexanoyl)-glycine, ethyl ester are dissolved in 200 ml of ethanol, and 6.5 g (0.1 mol) of powdered potassium cyanide are added. The reaction mixture is brought to the reflux point and stirred under reflux for 15 hours. After concentration of the mixture under reduced pressure, the residue is taken up with dichloromethane and the organic phase is washed with aqueous sodium chloride solution. The organic phase is dried and concentrated under reduced pressure to give 19 g of the expected product (yield=99%).

후처리

  1. temperatureunder reflux for 15 hours
  2. washthe organic phase is washed with aqueous sodium chloride solution
  3. customThe organic phase is dried
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f0e0f1638dcd40c780aa7d8ec6375945
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733928

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