Isopropylamine → 3-Chloro-N-(propan-2-yl)pyrazin-2-amine
반응식
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][CH:10]([NH2:12])[CH3:11]>C1COCC1>[Cl:8][C:7]1[C:2]([NH:12][CH:10]([CH3:11])[CH3:9])=[N:3][CH:4]=[CH:5][N:6]=1참가 물질
4
실험 절차
2,3-dichloropyrazine (10 g, 67.1 mmol), propan-2-amine (11.90 g, 201 mmol), and 50 mL of THF were mixed in a three-neck flask and stirred at room temperature overnight. The reaction was brought to reflux overnight. The reaction was cooled and the solvent was evaporated. The residue was dissolved in dichloromethane and the salt was filtered. The solvent was then evaporated and the residue was purified by column using dichloromethane as solvent to give 3-chloro-N-isopropylpyrazin-2-amine (6.2 g, 53.8%).
후처리
- temperatureto reflux overnight
- temperatureThe reaction was cooled
- customthe solvent was evaporated
- dissolutionThe residue was dissolved in dichloromethane
- filtrationthe salt was filtered
- customThe solvent was then evaporated
- customthe residue was purified by column
출처 및 근거
- ORD 기록
- ord-2f52f21493e84c5caa5d10d5da1134e0
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883322B2
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