Ethanol → 2-Ethylamino-3-nitropyridine

반응식

Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12].C(O)C>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]

참가 물질

반응물 3

HCID 702Ethanol

HCID 6341Ethylamine

HCID 796132-Chloro-3-nitropyridine

생성물 1

HCID 120157272-Ethylamino-3-nitropyridine수율 92%

실험 절차

2-Chloro-3-nitropyridine (20.00 g, 126 mmol) was added to ethylamine in ethanol (40 mL, 80 mmol) at room temperature and kept overnight. The solution was evaporated, the residue was diluted with 150 mL of EtOAc, washed with aqueous NaHCO3 and purified by column chromatography on silica gel (hexane/ethyl acetate 4/1) to give yellow solid (19.5 g, 92%).

후처리

customThe solution was evaporated
additionthe residue was diluted with 150 mL of EtOAc
washwashed with aqueous NaHCO3
custompurified by column chromatography on silica gel (hexane/ethyl acetate 4/1)

출처 및 근거

ORD 기록: ord-73ac23f5c8694659b3474991d37be063
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08883322B2

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