Potassium Carbonate → Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

HRID 33365

반응식

HRID 33365 반응식
F[C:2]1[CH:3]=[C:4]([CH3:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:12][C:13]([CH3:25])([CH3:24])[CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:25][C:13]([NH:12][C:2]1[CH:3]=[C:4]([CH3:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9])([CH3:24])[CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 45072486tert-butyl N-(3-amino-3-methylbutyl)carbamate

생성물 1

HCID 86603965Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.0 g (12.9 mmol) 3-fluoro-4-nitro-toluene, 2.6 g (13.0 mmol) tert-butyl (3-amino-3-methyl-butyl)-carbamate and 2.3 g (16.8 mmol) potassium carbonate are stirred overnight at ambient temperature in 20 mL DMF. The solvent is distilled off and the residue is combined with ethyl acetate. The mixture is washed repeatedly with water, dried with sodium sulphate and the solvent is eliminated. 4.8 g yellow oil. Mass spectroscopy: [M+H]+=338.

후처리

  1. distillationThe solvent is distilled off
  2. washThe mixture is washed repeatedly with water
  3. dry with materialdried with sodium sulphate

출처 및 근거

ORD 기록
ord-0f0c11cfd1dc4952bf8cc9718579b0c3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429583B2

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