Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Asulam → Methyl 4-(3-(3,4-dichlorobenzyl)ureido)phenylsulfonylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Asulam | HCID 18752 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1,2-Dichloro-4-(isocyanatomethyl)benzene | HCID 2733368 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Methyl 4-(3-(3,4-dichlorobenzyl)ureido)phenylsulfonylcarbamate | HCID 25120648 | — |
반응 단계
A solution of methyl 4-aminophenylsulfonylcarbamate (50 mg, 0.2 mmol), N,N-diisopropylethylamine (35 L, 0.2 mmol), 3,4-dichlorobenzylisocyanate (30 L, 0.2 mmol) in acetonitrile was stirred under an N2 atmosphere for 19 h. The mixture was concentrated and the residue purified by reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give methyl 4-(3-(3,4-dichlorobenzyl)ureido)phenylsulfonylcarbamate. LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=431.01; tR=2.9 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883766B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-4717ed95419a4007a1a499480128a54d |
| 출처 메모 | uspto-grants-2014_11 |