2-Methoxybenzoyl chloride → HCID 59026631, 화합물

HRID 333705노트

반응식

HRID 333705 반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[S:4][C:3]=1[C:14]#[N:15].[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>N1C=CC=CC=1>[C:14]([C:3]1[S:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)=[CH:6][C:2]=1[NH:1][C:20](=[O:21])[C:19]1[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=1[O:17][CH3:16])#[N:15]

참가 물질

4

반응물 2

HCID 889692-Methoxybenzoyl chlorideHCID 27358943-Amino-5-(4-fluorophenyl)thiophene-2-carbonitrile

생성물 1

HCID 59026631HCID 59026631, 화합물수율 74%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 3-amino-5-(4-fluorophenyl)thiophene-2-carbonitrile (2.0 g, 9.2 mmol) in pyridine (40 mL) was cooled in an ice bath, and 2-methoxybenzoyl chloride (1.2 mL, 9.2 mmol) was added dropwise. The cooling bath was removed, and the reaction was stirred for 16 h. The reaction was poured into water, and the resulting suspension was acidified with 1 M hydrochloric acid. The solid was filtered, washed with water, and dried under vacuum to give N-(2-cyano-5-(4-fluorophenyl)thiophen-3-yl)-2-methoxybenzamide (2.4 g, 74% yield).

후처리

  1. customThe cooling bath was removed
  2. additionThe reaction was poured into water
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-30b0592c3f954f3bae612b0fd9ec7d79
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883781B2

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