2,4-Dichloroquinoline → 4-Chloro-6-methoxyquinoline

HRID 333925

반응식

HRID 333925 반응식
Cl[C:2]1[CH:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:13])[CH:8]=2)[N:3]=[CH:2][CH:11]=1

참가 물질

4

반응물 2

HCID 6075032,4-DichloroquinolineHCID 10942334Sodium Methoxide

생성물 1

HCID 2283484-Chloro-6-methoxyquinoline수율 86%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

2,4-Dichloroquinoline (2.5 g, 12.6 mmol) was dissolved in anhydrous toluene (20 ml), a suspension of sodium methoxide (2.5 g, 46.3 mmol) in anhydrous toluene (20 ml) was added and the mixture was heated under reflux for 16 hours. After cooling to room temperature the suspension was filtered, the filter cake washed once with toluene (50 ml), the combined filtrates were evaporated under reduced pressure to dryness to yield 2.1 g (10.8 mmol, 86%) of a red solid. MS (ES) m/z=193.1 [M+H]+.

후처리

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 16 hours
  4. filtrationwas filtered
  5. washthe filter cake washed once with toluene (50 ml)
  6. customthe combined filtrates were evaporated under reduced pressure to dryness

출처 및 근거

ORD 기록
ord-ea9c16e87f9848afa81e95787bee821b
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883791B2

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