Triethylamine → (E)-4-Methyl-1-[4-(4-quinolyl)-1-piperidyl]pent-2-en-1-one

HRID 333929노트

반응식

HRID 333929 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:24][CH:25]([CH3:31])/[CH:26]=[CH:27]/[C:28](Cl)=[O:29]>ClCCl>[CH3:24][CH:25]([CH3:31])/[CH:26]=[CH:27]/[C:28]([N:1]1[CH2:2][CH2:3][CH:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[CH:9][CH:8]=2)[CH2:5][CH2:6]1)=[O:29]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10986269(E)-4-methylpent-2-enoyl ChlorideHCID 587708514-(Piperidin-4-yl)quinoline

생성물 1

HCID 56948962(E)-4-Methyl-1-[4-(4-quinolyl)-1-piperidyl]pent-2-en-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

4-(4-Piperidyl)quinoline (0.1 mmol, 21 mg) was dissolved in dichloromethane (1 ml). Triethylamine (1 ml of a 0.12M solution in dichloromethane) was added, the solution was shaken for 30 seconds and (E)-4-methylpent-2-enoyl chloride was added (1 ml of a 0.12 M solution in dichloromethane. The mixture was shaken for one hour at room temperature and evaporated to dryness under reduced pressure. The residue was purified by preparative HPLC. 5.1 mg were obtained (0.017 mmol, 17%).

후처리

  1. stirringThe mixture was shaken for one hour at room temperature
  2. customevaporated to dryness under reduced pressure
  3. customThe residue was purified by preparative HPLC
  4. custom5.1 mg were obtained (0.017 mmol, 17%)

출처 및 근거

ORD 기록
ord-9e5b2cb9e7024cf5a925ac2536913329
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883791B2

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