tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate → N-[(3S)-Pyrrolidin-3-yl]quinolin-4-amine
반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH:11][C@H:12]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]2)=[CH:3][CH:2]=1>ClCCl.FC(F)(F)C(O)=O>[NH:14]1[CH2:15][CH2:16][C@H:12]([NH:11][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)[CH2:13]1참가 물질
4
실험 절차
tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate (231 mg, 0.68 mmol) was dissolved in a 1:1 mixture of dichloromethane and trifluoroacetic acid (2 ml) and stirred at room temperature for 15 minutes. The mixture was evaporated to dryness under reduced pressure and the residue obtained was used directly in the next step.
후처리
- customThe mixture was evaporated to dryness under reduced pressure
- customthe residue obtained
출처 및 근거
- ORD 기록
- ord-2df75cc88bef4c0092b546ebb476418e
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883791B2
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