Phosphorus oxide (P4O10) → Ethyl (E)-4,4,5,5,5-pentafluoropent-2-enoate
반응식
[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[CH:3](O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[F:1][C:2]([F:15])([C:11]([F:12])([F:13])[F:14])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6]참가 물질
3
반응 조건
- 온도
- 140 °C
실험 절차
Ethyl 4,4,5,5,5-pentafluoro-3-hydroxy-pentanoate (11.9 g from step C) was placed in a 25 ml round-bottom flask and phosphorpentoxid was added in small portions until the educt was almost completely absorbed. The temperature was raised slowly to 140° C. until a brown syrup was obtained. The flask was connected to a distilling apparatus and the product isolated by distillation at reduced pressure (50 mbar, 50° C.). 5.5 g (25.2 mmol, 50% over 2 steps) were obtained which were used directly in the next step.
후처리
- customwas almost completely absorbed
- customwas obtained
- customthe product isolated by distillation at reduced pressure (50 mbar, 50° C.)
- custom5.5 g (25.2 mmol, 50% over 2 steps) were obtained which
출처 및 근거
- ORD 기록
- ord-79032a1d84ae4d9f8b79cf1f57bf3fc5
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883791B2
반응 노트
불러오는 중…