참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 4-Chloro-2-methyl-7-(trifluoromethyl)quinoline | HCID 4736805 | — |
| 용매 | 3-(3-Methoxypropoxy)-1-propanol | HCID 66984 | — |
| 생성물 | 2-Methyl-4-piperazin-1-yl-7-(trifluoromethyl)quinoline | HCID 66835798 | — |
반응 단계
2-Methyl-4-chloro-7-(trifluoromethyl)quinoline (1.1 g, 4.4 mmol) was dissolved in dipropyleneglycolmonomethylether, piperazine was added (12 g, 14 mmol) and the mixture was stirred at 140° C. overnight. The solvent was removed under reduced pressure and the residue purified by column chromatography (prepacked silica column, gradient ethyl acetate/methanol with the addition of 1% ammonia) to yield 1.07 g of a solid. (3.6 mmol, 82%) MS (APCI): m/z=295.8 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883791B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-374e4806ed4545ceb827d566c07fdfb5 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
