HCID 86688251, 화합물 → (3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

HRID 334021노트

반응식

HRID 334021 반응식
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13][C:12]1([CH3:28])[CH3:27])=O)C1C=CC=CC=1>[Pd].CO>[CH3:27][C:12]1([CH3:28])[NH:11][CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13]1

참가 물질

4

반응물 1

HCID 86688251HCID 86688251, 화합물

생성물 1

HCID 86688252(3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 1.10 g (2.87 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester and 100 mg palladium on carbon in 20 mL methanol was hydrogenated at RT for 12 h at 3 bar. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-a19f4a0946e746b6bbd57e8f9b6473e4
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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