Ethyl 3-bromobenzoate → 3-Cyclobutylbenzoic acid

반응식

Br[C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7]CC)=[O:6].[Br-].[CH:14]1([Zn+])[CH2:17][CH2:16][CH2:15]1.C1(C2C(C(O)=O)=CC=CC=2)CCCC1>>[CH:14]1([C:2]2[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=2)[C:5]([OH:7])=[O:6])[CH2:17][CH2:16][CH2:15]1

참가 물질

반응물 3

HCID 90488Ethyl 3-bromobenzoate

HCID 227631552-Cyclopentylbenzoic acid

HCID 178419766HCID 178419766, 화합물

생성물 1

HCID 838275863-Cyclobutylbenzoic acid

실험 절차

This intermediate was prepared from ethyl 3-bromobenzoate and cyclobutylzinc bromide in two steps according to the preparation of 6-cyclopentyl-benzoic acid.

출처 및 근거

ORD 기록: ord-392a5b975cba41a98c4adb39305ca4b7
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08883789B2

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