Bromine → 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione

HRID 334151노트

반응식

HRID 334151 반응식
[NH:1]1[C:6]2[CH:7]=[CH:8][S:9][C:5]=2[C:4](=[O:10])[NH:3][C:2]1=[O:11].[Br:12]Br>C(O)(=O)C>[Br:12][C:7]1[C:6]2[NH:1][C:2](=[O:11])[NH:3][C:4](=[O:10])[C:5]=2[S:9][CH:8]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 7059273Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 183264277-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione수율 60%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (10.38 g, 61.72 mmol) was dissolved in acetic acid (230 mL) and Bromine (11.13 mL, 216 mmol) was added. The reaction was heated at 80° C. for 3.5 h. Complete reaction was confirmed by LCMS. The reaction mixture was poured onto ice water slowly and filtered off the precipitate which was dried overnight under vacuum to give 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9.1 g, 60% yield)

후처리

  1. customComplete reaction
  2. additionThe reaction mixture was poured onto ice water slowly
  3. filtrationfiltered off the precipitate which
  4. customwas dried overnight under vacuum

출처 및 근거

ORD 기록
ord-2b62709c92634f6d93054bc037e3db69
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883799B2

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