1-(3-Fluorophenyl)piperazine → 1-(Biphenyl-2-ylmethyl)-4-(3-fluorophenyl)piperazine

HRID 334263

반응식

HRID 334263 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[C:14]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:15]([CH:20]=O)=[CH:16][CH:17]=[CH:18][CH:19]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[C:14]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][N:11]1[CH2:12][CH2:13][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH2:9][CH2:10]1

참가 물질

5

반응물 4

HCID 774181-(3-Fluorophenyl)piperazineHCID 121052(1,1'-Biphenyl)-2-carboxaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

생성물 1

HCID 716025251-(Biphenyl-2-ylmethyl)-4-(3-fluorophenyl)piperazine

실험 절차

80 mg of the target compound (0.23 mmol, 28.0%) was obtained using 1-(3-fluorophenyl)piperazine (296 mg, 1.64 mmol), biphenyl-2-carbaldehyde (150 mg, 0.82 mmol) and NaBH(OAc)3 (529 mg, 2.46 mmol) according to the synthesis method of Compound 1.

출처 및 근거

ORD 기록
ord-3568ed29fe7a4e2fb72001054040708f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883796B2

연결된 노트

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