1-(p-Tolyl)piperazine → 1-(Biphenyl-2-ylmethyl)-4-(4-methylphenyl)piperazine

HRID 334277

반응식

HRID 334277 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:14]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:15]([CH:20]=O)=[CH:16][CH:17]=[CH:18][CH:19]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[C:14]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][N:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1

참가 물질

5

반응물 4

HCID 831131-(p-Tolyl)piperazineHCID 121052(1,1'-Biphenyl)-2-carboxaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

생성물 1

HCID 716026401-(Biphenyl-2-ylmethyl)-4-(4-methylphenyl)piperazine

실험 절차

70.4 mg of the target compound (0.21 mmol, 47.7%) was obtained using 1-(4-methylphenyl)piperazine (155 mg, 0.88 mmol), biphenyl-2-carbaldehyde (80 mg, 0.44 mmol) and NaBH(OAc)3 (284 mg, 1.32 mmol) according to the synthesis method of Compound 1.

출처 및 근거

ORD 기록
ord-74c1411df83e4358b2eac4d6c1f495e6
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883796B2

연결된 노트

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