Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminobenzamide → 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminobenzamide | HCID 76079 | — |
| 반응물 | 4-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine | HCID 21905993 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide | HCID 10041964 | — |
반응 단계
To a solution of 4-(4-chlorophenyl)-2-(methylsulfonyl)pyrimidine (0.10 g, 0.37 mmol) and 4-aminobenzamide in 2-propanol (3 ml) was heated to 120° C. in a sealed vessel for 14 hours. The crude material was concentrated and purified by preparative HPLC to provide the title compound as a beige solid: LC/MS Retention Time; 6.30 min (Method A), M+1; 325.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429599B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-6d21f82bd72642048b2877c0ad5bb8de |
| 출처 메모 | uspto-grants-2008_09 |